The CTSA Program Data to Health Coordination Center (CD2H) will support a vibrant and evolving informatics ecosystem for the CTSA Program. The Oregon Health & Science University, Northwestern University, University of Washington, Johns Hopkins University School of Medicine, and Sage Bionetworks, together with The Scripps Research Institute, Washington University in St. Louis, The University of Iowa, and The Jackson Laboratory were funded in 2017 to implement CD2H.